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Histamine is released as a reaction to foreign substances (allergens), and starts a chain reaction that leads to the release of other chemicals that add to the allergic response. There are two different types of antihistamine; sedating antihistamines, which can enter the brain and cause drowsiness and non-sedating antihistamines which do not.

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Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist.

Daily use of an antihistamine, decongestant, or both can be considered either instead of or in addition to nasal steroids.

It is used for symptomatic treatment of seasonal and perennial allergic rhinitis and for chronic urticaria.

(NCI)A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma.

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